Discovery of a Spin-Down State Change in the LMC Pulsar B0540-69

We report the discovery of a large, sudden, and persistent increase in the spin-down rate of B0540-69, a young pulsar in the Large Magellanic Cloud, using observations from the Swift and RXTE satellites. The relative increase in the spin-down rate of 36% is unprecedented for B0540-69. No accompanying change in the spin rate is seen, and no change is seen in the pulsed X-ray emission from B0540-69 following the change in the spin-down rate. Such large relative changes in the spin-down rate are seen in the recently discovered class of 'intermittent pulsars', and we compare the properties of B0540-69 to such pulsars. We consider possible changes in the magnetosphere of the pulsar that could cause such a large change in the spin-down rate.Comment: 6 pages, 2 figures, accepted for publication in ApJ Letter

Molecular flexibility of citrus pectins by combined sedimentation and viscosity analysis

The flexibility/rigidity of pectins plays an important part in their structure-function relationship and therefore on their commercial applications in the food and biomedical industries. Earlier studies based on sedimentation analysis in the ultracentrifuge have focused on molecular weight distributions and qualitative and semi-quantitative descriptions based on power law and Wales-van Holde treatments of conformation in terms of "extended" conformations [Harding, S. E., Berth, G., Ball, A., Mitchell, J.R., & Garcìa de la Torre, J. (1991). The molecular weight distribution and conformation of citrus pectins in solution studied by hydrodynamics. Carbohydrate Polymers, 168, 1-15; Morris, G. A., Foster, T. J., & Harding, S.E. (2000). The effect of degree of esterification on the hydrodynamic properties of citrus pectin. Food Hydrocolloids, 14, 227-235]. In the present study, four pectins of low degree of esterification 17-27% and one of high degree of esterification (70%) were characterised in aqueous solution (0.1 M NaCl) in terms of intrinsic viscosity [η], sedimentation coefficient (s°20,w) and weight average molar mass (Mw). Solution conformation/flexibility was estimated qualitatively using the conformation zoning method [Pavlov, G.M., Rowe, A.J., & Harding, S.E. (1997). Conformation zoning of large molecules using the analytical ultracentrifuge. Trends in Analytical Chemistry, 16, 401-405] and quantitatively (persistence length Lp) using the traditional Bohdanecky and Yamakawa-Fujii relations combined together by minimisation of a target function. Sedimentation conformation zoning showed an extended coil (Type C) conformation and persistence lengths all within the range Lp=10-13 nm (for a fixed mass per unit length)

Continuum and spectral line observations of the OH Megamaser galaxy Arp 220

We present MERLIN observations of the continuum (both 1.6 and 5 GHz) and OH maser emission towards Arp220. the correct spatial configuration of the various componnents of the galaxy is revealed. In the eastern component the masers are shown to be generally coincident with the larger scale continuum emission; in the west, the masers and continuum do not generally arise from the same location. A velocity gradient (0.32+/-0.03km/s/pc) is found in the eastern nuclear region in MERLIN scales; this gradient is three times smaller than seen in OH and implies that the OH gas lies inside the HI. A re-analysis of previously presented global VLBI data (Lonsdale et al. 1998) reveals a very high velocity gradient (18.67+/-0.12km/s/pc) in one component, possibly the site of a heavily obscured AGN.Comment: 10 pages, 11 figures, accepted by MNRA

Multiwavelength radio observations of the compact starburst in Arp 220

We report the first detection at multiple radio wavelengths (13, 6, and 3.6 cm) of 18 compact sources within both nuclei of the Ultra Luminous Infra-Red Galaxy (ULIRG) Arp 220. In just over half of the sources we find that the observed spectra are consistent with the standard model of powerful Type IIn supernovae interacting with their pre-explosion stellar wind. The rate of appearance of new radio sources ascribed to these supernova events suggests that a large fraction of core-collapse supernovae in Arp 220 are highly luminous, possibly implying a radically different stellar initial mass function (IMF) or stellar evolution compared to galactic disks. A second group of sources, consisting of the brightest and longest monitored sources at 18 cm, do not easily fit the radio supernova model. We propose that these are young supernova remnants that have just begun interacting with their surrounding dense ISM

Developing sexual competence? Exploring strategies for the provision of effective sexualities and relationships education

School-based sexualities and relationships education (SRE) offers one of the most promising means of improving young people's sexual health through developing 'sexual competence'. In the absence of evidence on whether the term holds the same meanings for young people and adults (e.g. teachers, researchers, policy-makers), the paper explores 'adult' notions of sexual competence as construed in research data and alluded to in UK Government guidance on SRE, then draws on empirical research with young people on factors that affect the contexts, motivations and outcomes of sexual encounters, and therefore have implications for sexual competence. These data from young people also challenge more traditional approaches to sexualities education in highlighting disjunctions between the content of school-based input and their reported sexual experience. The paper concludes by considering the implications of these insights for developing a shared notion of what SRE is trying to achieve and suggestions for recognition in the content and approaches to SRE.</p

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.

Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis. Here, we investigate how Toll-like receptor-MyD88 signaling in myeloid and endothelial cells coordinately participates in the initiation and progression of high fat diet-induced systemic inflammation and metabolic inflammatory diseases. MyD88 deficiency in myeloid cells inhibits macrophage recruitment to adipose tissue and their switch to an M1-like phenotype. This is accompanied by substantially reduced diet-induced systemic inflammation, insulin resistance, and atherosclerosis. MyD88 deficiency in endothelial cells results in a moderate reduction in diet-induced adipose macrophage infiltration and M1 polarization, selective insulin sensitivity in adipose tissue, and amelioration of spontaneous atherosclerosis. Both in vivo and ex vivo studies suggest that MyD88-dependent GM-CSF production from the endothelial cells might play a critical role in the initiation of obesity-associated inflammation and development of atherosclerosis by priming the monocytes in the adipose and arterial tissues to differentiate into M1-like inflammatory macrophages. Collectively, these results implicate a critical MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases

The importance of the bacterial cell wall in uranium(VI) biosorption.

The bacterial cell envelope, in particular the cell wall, is considered the main controlling factor in the biosorption of aqueous uranium(vi) by microorganisms. However, the specific roles of the cell wall, associated biomolecules, and other components of the cell envelope are not well defined. Here we report findings on the biosorption of uranium by isolated cell envelope components and associated biomolecules, with P. putida 33015 and B. subtilis 168 investigated as representative strains for the differences in Gram-negative and Gram-positive cell envelope architecture, respectively. The cell wall and cell surface membrane were isolated from intact cells and characterised by X-ray Photoelectron Spectroscopy (XPS) and Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FT-IR) spectroscopy; revealing variations in the abundance of functional moieties and biomolecules associated with components of the cell envelope. Uranium biosorption was investigated as a function of cell envelope component and pH, comparing with intact cells. The isolated cell wall from both strains exhibited the greatest uranium biosorption capacity. Deprotonation of favourable functional groups on the biomass as the pH increased from 3 to 5.5 increased their uranium biosorption capacity by approximately 3 fold. The results from ATR-FT-IR indicated that uranium(vi) biosorption was mediated by phosphate and carboxyl groups associated with proteins and phosphorylated biopolymers of the cell envelope. This includes outer membrane phospholipids and LPS of Gram-negative bacteria and teichoic acids, surface proteins and peptidoglycan from Gram-positive bacteria. As a result, the biosorption process of uranium(vi) to microorganisms is controlled by surface interactions, resulting in higher accumulation of uranium in the cell envelope. This demonstrates the importance of bacterial cell wall as the key mediator of uranium biosorption with microorganisms

VLBI Images of 49 Radio Supernovae in Arp 220

We have used a Very Long Baseline Interferometry (VLBI) array at 18cm wavelength to image the nucleus of the luminous IR galaxy Arp 220 at ~1 pc linear resolution, and with very high sensitivity. The resulting map has an rms of 5.5 microJy/beam, and careful image analysis results in 49 confirmed point sources ranging in flux density from 1.2 mJy down to ~60 microJy. Comparison with high sensitivity data from 12 months earlier reveals at least four new sources. The favored interpretation of these sources is that they are radio supernovae, and if all new supernovae are detectable at this sensitivity, a resulting estimate of the supernova rate in the Arp 220 system is 4 +/- 2 per year. The implied star formation rate is sufficient to power the entire observed far-infrared luminosity of the galaxy. The two nuclei of Arp 220 exhibit striking similarities in their radio properties, though the western nucleus is more compact, and appears to be ~3 times more luminous than the eastern nucleus. There are also some puzzling differences, and differential free-free absorption, synchrotron aging and expansion losses may all be playing a role. Comparison with the nearby starburst galaxy M82 supports the hypothesis that the activity in Arp 220 is essentially a scaled-up version of that in M82.Comment: 24 pages, 3 figures, 1 table. Accepted for publication in Ap.